Paul Ehrlich Paul Ehrlich Euro-PhD Network & MuTaLig COST Action meeting 2019
Catanzaro (Italy), June 13th-15th 2019
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Scientific program


Thursday, June 13th 2019

 

13:30

Registration and welcome coffee (cloister) 

 

1st floor plenary room

15:00

Introduction to the IX Paul Ehrlich Euro-PhD network meeting       

Stefano ALCARO (CA15135 Chair and Paul Ehrlich network Coordinator) - UMG di Catanzaro (Italy)

Welcome greetings from the authorities 

Giovambattista DE SARRO Rector of Università “Magna Græcia” di Catanzaro (Italy)

Maria PAVIA Director of the Health Department - Università “Magna Græcia” di Catanzaro (Italy)

                  Session PE I – Celebration of the first ten years of the Paul Ehrlich Euro-PhD Network 

                  Moderator: Stefano ALCARO, Università “Magna Græcia” di Catanzaro (Italy)

15:30

PE-PL1 

Paul Ehrlich Euro-PhD Network: from 2 to 53 members

Girolamo CIRRINCIONE

Università degli Studi di Palermo (Italy)

16:00

PE-PL2 

Development of chemical tools for nucleotide and lipid receptor-like orphan G protein-coupled receptors           

Christa E. MÜLLER

Rheinische Friedrich-Wilhelms-Universität, Bonn, (Germany)

                  Session PE II – Paul Ehrlich Euro-PhD Network PhD awarding ceremony 

                  Moderator:  Serge VAN CALENBERGH,  University of Ghent (Belgium)

16:30

PE-SC_1 

Computational studies on MAO-B and AChE inhibitors as potential anti-Parkinson's and anti-Alzheimer's agents   

Donatella BAGETTA

Università “Magna Græcia” di Catanzaro (Italy) – PE awarded

16:45

PE-SC_2 

Design and chemical optimization of 3-phenylquinolone derivatives as potent nontuberculous mycobacteria efflux inhibitors

Tommaso FELICETTI

University of Perugia (Italy) – PE awarded

17:00

PE-SC_3 

PEGylation technology – the second chance for non-bioavailable drug candidates                                 

Carlos FERNANDES

University of Porto (Portugal) – PE awarded

17:15

PE-SC_4 

Identification of new 4-fluorobenzyl-analogs as tyrosinase inhibitors via computational studies, synthesis and biological evaluation

                                                                                                                                                                                                              Laura IELO

University of Messina (Italy) – PE awarded

17:30

PE-SC_5 

Molecular modeling of epitopes recognized by neoplastic B-cells in Chronic Lymphocytic Leukemia                         

Antonio LUPIA

Università “Magna Græcia” di Catanzaro (Italy) – PE awarded

17:45

PE-SC_6 

Design and development of multi-target agents for neurodegenerative diseases (video presentation)

Ester Sofia BENFEITO

University of Porto (Portugal) – PE awarded 

18:00       Introduction and tour to the ROMANO CARRATELLI Codex exposition at San Giovanni Museum 

19:00       Free welcome party at the Complesso Monumentale San Giovanni (cloister)

22:30       Return to hotels (bus shuttle for registered participants)

 


Friday, June 14th 2019

 

basing floor GISSING room

 

1st floor plenary room

Session PE III – Novel chemical entities

Moderator: Athina GERONIKAKI (Greece)

 

Session MuTaLig I – Anti-neurodegenerative agents

Moderator: Fernanda BORGES (Portugal)

 

 

 

9:00

Introduction to  IV MuTaLig annual meeting

9:15      

PE-SC_7

 

Pyrido[2,3-d]pyrimidine-7(8H)-ones: synthesis and biomedical applications

José I. BORRELL

Universitat Ramon Llull, Barcelona (Spain) 

 

9:15      

CA-SC_1 

Maintaining the neuro-transmitter pool in degenerating brain: parameters for propargylamine inhibition of monoamine oxidase

Rona RAMSAY

University of St Andrews (United Kingdom)

9:30      

PE-SC_8 

Design and Development of New Chemical Concepts via Controlled Generation of Unstable Carbenoids Species

Vittorio PACE

University of Vienna (Austria)

 

9:30      

CA-SC_2 

Expanding the coumarin toolbox directed at CNS multitargeting agents

 

Leonardo PISANI

University “Aldo Moro”, Bari (Italy)

9:45      

PE-SC_9 

Lessons from black pepper: moving from one to multitarget-directed ligands by diversity-oriented synthesis

Daniel CHAVARRIA

University of Porto (Portugal)

 

9:45      

CA-SC_3 

4-(3-Nitrophenyl)thiazol-2-ylhydra-zone derivatives as selective hMAO-B inhibitors: synthesis, bio-logical activity and computational analysis

Giulia ROTONDI

Sapienza University, Rome (Italy)

10:00   

PE-SC_10

Position-Selective Synthesis and Biological Evaluation of Four Isomeric A-Ring Amino Derivatives of the Alkaloid Luotonin A

Amra IBRIC

University of Vienna (Austria)

 

10:00   

CA-SC_4

Probing fluorine-effects in multitarget anti-Alzheimer agents

 

Mariagrazia RULLO

University “Aldo Moro”, Bari (Italy)

10:15   

PE-SC_11

Synthesis of Cytotoxic Isoquinolinequinone N-oxides as Multitargeted Agents

Ryan D. Kruschel

University College, Cork (Ireland)

 

10:15   

CA-SC_5 

Novel Chromane Derivatives for Alzheimer’s Disease

Anthony BURKE

University of Évora (Portugal)

10:30   

PE-SC_12

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold

Silvia BALDUCCI

Sapienza University, Rome (Italy)

 

10:30   

CA-SC_6

Looking for the Pharmacophore of Benzopyran MAO-B Inhibitors

 

Francesco MESITI

Università “Magna Græcia” di Catanzaro (Italy)

10:45       Coffee break (cloister)

11:15       Poster session multimedia exposition  - small rooms at the basing floor

 

 

 

 

 

basing floor GISSING room

 

1st floor plenary room

Session PE IV – Anti-microbial agents

Moderator: Danijel KIKELJ (Slovenia)

 

Session MuTaLig II – Anti-cancer agents

Moderator: Eugenio GAUDIO (Switzerland)

11:45   

PE-SC_13 

 

Multi-target design of arginase inhibitors for Leishmania

 

Alfonso T. GARCÍA-SOSA

University of Tartu (Estonia)

 

11:45   

CA-SC_7 

Protein-protein interaction studies on thymidylate synthase leads to the identification and characterization of interface inhibitors as anticancer agents.

Maria Paola COSTI

University of Modena e Reggio Emilia (Italy)

12:00   

PE-SC_14 

Synthesis and biological evaluation of 1’-N-homoazanucleosides: discovery of a 5’-methyl-thioadenosine analogue with antitrypanosomal activity

Jakob BOUTON

University of Ghent (Belgium)

 

12:00   

CA-SC_8

 

A candidate multi-targeting approach to block the CD98hc oncoprotein 

 

Francesco TRAPASSO

Università “Magna Græcia” di Catanzaro (Italy)

12:15   

PE-SC_15

Halogenated phenothiazines targeting the M. Tuberculosis type II of the NADH dehydrogenase.

Maria Giulia NIZI

University of Perugia (Italy)

 

12:15   

CA-SC_9

The untranslated region of the BCL2 gene and its noncanonical secondary structures

Camilla CRISTOFARI

University of Padova (Italy)

12:30   

PE-SC_16

In vitro Activities of a New Fluoroquinolone Derivative Highly Active against Chlamydia trachomatis.

Nawal SERRADJI

University of Paris Sud (France)

 

12:30   

CA-SC_10

 

Multi-enzyme inhibitors for the treatment of cancer

 

Serenella DEPLANO

University of Cagliari (Italy)

12:45   

PE-SC_17

Design and synthesis of Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitors

                                                                            Yanlin JIAN

University of Ghent (Belgium)

 

12:45   

CA-SC_11

Development of NO-releasing sigma receptor hybrids as anticancer agents

 

Maria DICHIARA

University of Catania (Italy)

 

 

 

 

 

13:00       Lunch (cloister)

14:15       Poster session multimedia exposition - small rooms at the basing floor

 

 

 

basing floor GISSING room

 

1st floor plenary room

 

 

Session MuTaLig III: Advanced computational methods 

 

Moderator: Vittorio LIMONGELLI, USI Lugano (Switzerland)

 

14:45   

CA-SC_12

Computational tools for multi-target drug discovery

2Hanoch SENDEROWITZ

University of Bar Ilan, Ramat-Gan (Israel)

15:00 Paul Ehrlich Euro-PhD network coordinator meeting

 

15:00   

CA-SC_13

In silico methods for multi-target drug development

Agnieszka A. KACZOR

University of Lublin (Poland)

 

15:15

CA-SC_14

Combined FAAH and COX inhibition by Flurbiprofen amide derivatives for the treatment of pain and inflammation

Federica MORACA

University “Federico II”, Napoli (Italy)

 

15:30   

CA-SC_15

On the inhibition mechanism of glutathione transferase p1 by piperlongumine. Insight from theory.

Mario PREJANÒ

Università della Calabria, Rende (Italy)

 

15:45   

CA-SC_16

In silico repurposing of the hexahydrocyclo-penta[c]quinoline scaffold as potent Carbonic Anhydrase inhibitors

Annachiara TINIVELLA

University of Modena e Reggio Emilia (Italy)

 

 

 

16:00       Coffee break (cloister)

16:15       Poster session multimedia exposition - small rooms at the basing floor

17:00       Social activity for booked participants only (optional)

 


Saturday, June 15th 2019

 

basing floor GISSING room

9:00         Welcome coffee (cloister) 

9:30         Best poster voting deadline

 

 

9:30 MuTaLig MC meeting (MC members only)

 

 

 

1st floor plenary room

                  Session MuTaLig IV – Opportunities for cooperation research projects

                  Moderator: Maria Laura Bolognesi, Alma Mater Studiorum, University of Bologna (Italy)

10:30

CA-SC_17 

Marie SkÅ‚odowska-Curie Actions – mobility and training for researchers        

Frank MARX

Deputy Head of Unit, Research Executive Agency, Bruxelles (Belgium) 

10:45

CA-SC_18

The Innovative Medicines Initiative: Europe’s partnership for health              

Gianluca SBARDELLA

(MC substitute for Italy) University of Salerno (Italy) 

11:00

CA-SC_19

Calabria regional policies for research and innovation

Menotti LUCCHETTA

Regione Calabria, Catanzaro (Italy)

11:15

CA-SC_20

Exploitation of Research Results: European fund and network       

Antonio MAZZEI

 CalabriaInnova-Fincalabra, Settingiano, Catanzaro (Italy)

11:30       Joint Paul Ehrlich and MuTaLig round table and best poster(s) awarding ceremony

                  Best poster award released by Sharon BRYANT, CEO of Inte:Ligand GmbH, Vienna (Austria)

                  Best poster award released by Rita PODZUNA, Director of Schrödinger GmbH, Mannheim (Germany)

                  Announcements about next Paul Ehrlich and MuTaLig meetings

12:30       Joint Paul Ehrlich and MuTaLig meeting concluding remarks

12:45       Social activity with lunch for booked participants only (optional)

 

MuTaLig

With the support of:

UMG

Dipartimento di Scienze della Salute

PhD

FUMG

ORDINE FARMACISTI CZ

FONDAZIONE CADUCEO

Correale

EJMEDCHEM

S-IN

EXACTAOPTECH