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Sala GISSIN - basing floor
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Sala delle Arti - 1st floor
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Session PE III – Novel chemical entities
Moderator: Athina GERONIKAKI (Greece)
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Session MuTaLig I – Anti-neurodegenerative agents
Moderator: Fernanda BORGES (Portugal)
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9:00
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Introduction to IV MuTaLig annual meeting
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9:15
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PE-SC_7
Pyrido[2,3-d]pyrimidine-7(8H)-ones: synthesis and biomedical applications
José I. BORRELL
Universitat Ramon Llull, Barcelona (Spain)
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9:15
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CA-SC_1
Maintaining the neuro-transmitter pool in degenerating brain: parameters for propargylamine inhibition of monoamine oxidase
Rona RAMSAY
University of St Andrews (United Kingdom)
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9:30
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PE-SC_8
Design and Development of New Chemical Concepts via Controlled Generation of Unstable Carbenoids Species
Vittorio PACE
University of Vienna (Austria)
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9:30
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CA-SC_2
Expanding the coumarin toolbox directed at CNS multitargeting agents
Leonardo PISANI
University “Aldo Moro”, Bari (Italy)
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9:45
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PE-SC_9
Lessons from black pepper: moving from one to multitarget-directed ligands by diversity-oriented synthesis
Daniel CHAVARRIA
University of Porto (Portugal)
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9:45
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CA-SC_3
4-(3-Nitrophenyl)thiazol-2-ylhydra-zone derivatives as selective hMAO-B inhibitors: synthesis, bio-logical activity and computational analysis
Giulia ROTONDI
Sapienza University, Rome (Italy)
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10:00
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PE-SC_10
Position-Selective Synthesis and Biological Evaluation of Four Isomeric A-Ring Amino Derivatives of the Alkaloid Luotonin A
Amra IBRIC
University of Vienna (Austria)
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10:00
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CA-SC_4
Probing fluorine-effects in multitarget anti-Alzheimer agents
Mariagrazia RULLO
University “Aldo Moro”, Bari (Italy)
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10:15
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PE-SC_11
Synthesis of Cytotoxic Isoquinolinequinone N-oxides as Multitargeted Agents
Ryan D. Kruschel
University College, Cork (Ireland)
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10:15
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CA-SC_5
Novel Chromane Derivatives for Alzheimer’s Disease
Anthony BURKE
University of Évora (Portugal)
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10:30
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PE-SC_12
Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold
Silvia BALDUCCI
Sapienza University, Rome (Italy)
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10:30
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CA-SC_6
Looking for the Pharmacophore of Benzopyran MAO-B Inhibitors
Francesco MESITI
Università “Magna Græcia” di Catanzaro (Italy)
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10:45 Coffee break (cloister)
11:15 Poster session multimedia exposition - small rooms at the basing floor
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Sala GISSING - basing floor
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Sala delle Arti - 1st floor
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Session PE IV – Anti-microbial agents
Moderator: Danijel KIKELJ (Slovenia)
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Session MuTaLig II – Anti-cancer agents
Moderator: Eugenio GAUDIO (Switzerland)
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11:45
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PE-SC_13
Multi-target design of arginase inhibitors for Leishmania
Alfonso T. GARCÍA-SOSA
University of Tartu (Estonia)
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11:45
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CA-SC_7
Protein-protein interaction studies on thymidylate synthase leads to the identification and characterization of interface inhibitors as anticancer agents.
Maria Paola COSTI
University of Modena e Reggio Emilia (Italy)
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12:00
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PE-SC_14
Synthesis and biological evaluation of 1’-N-homoazanucleosides: discovery of a 5’-methyl-thioadenosine analogue with antitrypanosomal activity
Jakob BOUTON
University of Ghent (Belgium)
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12:00
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CA-SC_8
A candidate multi-targeting approach to block the CD98hc oncoprotein
Francesco TRAPASSO
Università “Magna Græcia” di Catanzaro (Italy)
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12:15
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PE-SC_15
Halogenated phenothiazines targeting the M. Tuberculosis type II of the NADH dehydrogenase.
Maria Giulia NIZI
University of Perugia (Italy)
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12:15
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CA-SC_9
The untranslated region of the BCL2 gene and its noncanonical secondary structures
Camilla CRISTOFARI
University of Padova (Italy)
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12:30
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PE-SC_16
A target for macrocyclic antifungals: the needle in the haystack.
Diego FIORUCCI
Università di Siena (Italy)
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12:30
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CA-SC_10
Multi-enzyme inhibitors for the treatment of cancer
Serenella DEPLANO
University of Cagliari (Italy)
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12:45
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PE-SC_17
Design and synthesis of Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitors
Yanlin JIAN
University of Ghent (Belgium)
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12:45
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CA-SC_11
Development of NO-releasing sigma receptor hybrids as anticancer agents
Maria DICHIARA
University of Catania (Italy)
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13:00 Lunch (cloister)
14:15 Poster session multimedia exposition - small rooms at the basing floor
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Sala GISSING - basing floor
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Sala delle Arti - 1st floor
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Session MuTaLig III: Advanced computational methods
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Moderator: Vittorio LIMONGELLI, USI Lugano (Switzerland)
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14:45
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CA-SC_12
Computational tools for multi-target drug discovery
Hanoch SENDEROWITZ
University of Bar Ilan, Ramat-Gan (Israel)
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15:00 Paul Ehrlich Euro-PhD network coordinator meeting
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15:00
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CA-SC_13
In silico methods for multi-target drug development
Agnieszka A. KACZOR
University of Lublin (Poland)
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15:15
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CA-SC_14
Combined FAAH and COX inhibition by Flurbiprofen amide derivatives for the treatment of pain and inflammation
Federica MORACA
University “Federico II”, Napoli (Italy)
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15:30
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CA-SC_15
On the inhibition mechanism of glutathione transferase p1 by piperlongumine. Insight from theory.
Mario PREJANÒ
Università della Calabria, Rende (Italy)
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15:45
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CA-SC_16
In silico repurposing of the hexahydrocyclo-penta[c]quinoline scaffold as potent Carbonic Anhydrase inhibitors
Annachiara TINIVELLA
University of Modena e Reggio Emilia (Italy)
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16:00 Coffee break (cloister)
16:15 Poster session multimedia exposition - small rooms at the basing floor
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17:00 Social activity for booked participants only (optional)
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